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Protein Production and Characterization Associate Director

Posted: December 7, 2023 Expired: February 22, 2024
16 Year

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate:Biomedicines has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 275 employees.

The Role:

Generate:Biomedicines is seeking an experienced, highly motivated, and innovative Associate Director to be a part of a growing Protein Sciences department that is leveraging automated high-throughput platforms in multiple areas of protein production and characterization workflows. The individual will contribute to and manage workflows that include construct design, protein expression, purification, and biophysical/structural characterization of proteins across diverse modalities and scales. They will work collaboratively with the team and manage direct reports to develop, optimize, and execute methodologies in the production and characterization of complex protein modalities with varying biochemistries. They will be responsible for onboarding new technologies, increasing automation and throughput, training and managing of junior team members, designing experiments and communicating findings cross-functionally, maintaining detailed records, and generating standard operating procedures. This position will also include the responsibility to be a functional representative for different project teams with the potential to lead projects as well. This is an exciting opportunity to be part of a fast-paced, start-up environment, with a great culture.

Here's how you will contribute:

  • Protein construct design across a wide range of protein types and modalities to support project teams
  • Developing and optimizing methods for the expression, purification, and biophysical characterization of different protein modalities at small and large scales
  • Explore, assess and bring in-house new technologies in the relevant areas that are state-of-the-art and will enhance the internal platform to continuously improve efficiencies
  • Be an outstanding leader and collaborator, a creative problem solver, and a role model for your direct reports and colleagues
  • Serve as a subject matter expert in the area of protein production and characterization across different cross-functional teams
  • Serve as a Protein Science representative on project teams and participate in data presentations and cross-functional collaborations with opportunity to serve as Project Lead
  • Detailed documentation of data and analysis
  • Direct management, training, and/or mentorship of other team members
  • Some benchwork will be required

The ideal candidate will have:

  • PhD /9+ yrs. relevant experience, BS/MS with 16+ years of relevant experience, preferably in industry
  • Expression of proteins in different host systems such as mammalian (transient and/or stable) and bacterial. Experience with cell-free expression systems is a plus
  • Extended track record of being an outstanding leader and collaborator, a creative problem-solver, and a role model for your direct reports and colleagues
  • Molecular biology methodologies involved in DNA workflows
  • Small scale HT automation protein production as well as large scale protein purification chromatography-based methods
  • Protein biophysical characterization methodologies such as aSEC, SEC-MALS, SDS-page, Western blot, DSF, Octet, etc.
  • Prior industrial drug discovery experience working on cross-functional collaborative teams
  • Track record of creativity in successfully addressing challenging protein production
  • Commitment to growth and development of direct team members
  • Excellent attention to detail, documentation, and communication skills

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by Generate:Biomedicines's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines, and Generate will not owe any referral or other fees with respect thereto.


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